The Consumer’s Guide to Biologics for Atopic Dermatitis

Dupilumab is approved for people age 6 and older; tralokinumab-Idrm is approved for those age 18 and older.

There are many other types of biologics that have been available for decades, though, including ones that have been approved for a wide range of chronic inflammatory conditions, including Crohn’s disease, psoriasis, lupus, rheumatoid arthritis, and more.

As researchers have learned more about the body’s inflammatory system and all the complicated pathways that can trigger inflammation, more biologics have been developed, says Dr. Vij.

In addition, more biologics for atopic dermatitis may be in the pipeline, he says.

In general, dermatologists classify moderate atopic dermatitis as an outbreak of symptoms that affects about 10 percent of the surface area of your body, says Vij; severe atopic dermatitis affects about 30 to 40 percent. Not sure how much of your body is affected? Here’s a rough way to estimate the number: “The size of your palm is about 1 percent of your skin, so you count up the number of palm-sized areas that are affected,” says Vij.

People with more mild atopic dermatitis — for example, symptoms that don’t affect very much of their body and aren’t too bothersome — may be able to treat the condition with moisturizers or topical steroids during a flare, he says.

That said, there’s no magic formula for determining whether your condition is mild, moderate, or severe, which is why dermatologists also take other factors into consideration.

“It’s also about the global burden of atopic dermatitis on someone’s quality of life,” says Vij. For example, if your atopic dermatitis affects only a small area of your body, but that area is critical, such as your face, then you may want to consider a stronger medication, he says.

“If people are having problems at school or work or with their relationships, whether it’s normal friend relationships or sexual relationships, then we know their skin is having a greater cumulative effect than what you can just see,” Vij says.

Biologics for atopic dermatitis come as a prefilled syringe or pen that can be injected into the skin. Your doctor will tell you how much of the medication you should use and show you how to inject it. You may have to give yourself more than one injection, depending on your medication’s dosage.

You can inject yourself on the front of your thigh or on a part of your stomach that’s at least 2 inches away from your belly button. You’ll want to choose a different area each time you inject yourself so you don’t inject already tender skin).

Because biologics don’t suppress the immune system more broadly — like an immunosuppressant does — they’re less likely to trigger side effects, says Dr. Kwatra. In fact, because biologics work in such a targeted and specific way, the hope is that they are not only more effective but can also minimize other side effects, he says.

Right now, there doesn’t seem to be very many side effects with the biologic approved for atopic dermatitis, says Vij, but in some people, dupilumab can cause conjunctivitis (pink eye) or pain or swelling around the injection site. Some side effects of tralokinumab-Idrm can include eye and eyelid inflammation and pain or swelling around the injection sites.

A biologic doesn’t “cure” atopic dermatitis, but it can treat the condition for as long as you keep taking it, says Kwatra. “Once you start it, it’s usually a continuous treatment,” he says.

That said, there’s always the chance that a biologic may become less effective over time, although it’s too early to tell whether this is the case for the current biologics. (Dupilumab, the first biologic approved for atopic dermatitis, has only been on the market since 2017.)

“We know that, with other biologics, people develop antibodies to the medication,” says Vij, which diminishes the effect of the medication. It’s also possible — though not certain — that stopping and starting the medication could have the same effect, he explains.

“Time will tell,” he says.